GTX14515 WB Image
COMP antibody
GTX14515
ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Rat
Overview
- SupplierGeneTex
- Product NameCOMP antibody
- Delivery Days Customer10
- ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- HostRabbit
- IsotypeIgG
- Scientific DescriptionThe protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Contraction or expansion of a 5 aa aspartate repeat and other mutations can cause pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED). [provided by RefSeq, Jul 2016]
- ReactivityHuman, Mouse, Rat
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- A mouse model offers novel insights into the myopathy and tendinopathy often associated with pseudoachondroplasia and multiple epiphyseal dysplasia. Pirog KA et al., 2010 Jan 1, Hum Mol GenetRead more
- A novel form of chondrocyte stress is triggered by a COMP mutation causing pseudoachondroplasia. Suleman F et al., 2012 Jan, Hum MutatRead more
- A novel transgenic mouse model of growth plate dysplasia reveals that decreased chondrocyte proliferation due to chronic ER stress is a key factor in reduced bone growth. Gualeni B et al., 2013 Nov, Dis Model MechRead more
- A small molecule promotes cartilage extracellular matrix generation and inhibits osteoarthritis development. Shi Y et al., 2019 Apr 23, Nat CommunRead more
- Analysis of the cartilage proteome from three different mouse models of genetic skeletal diseases reveals common and discrete disease signatures. Bell PA et al., 2013 Aug 15, Biol OpenRead more
- Armet/Manf and Creld2 are components of a specialized ER stress response provoked by inappropriate formation of disulphide bonds: implications for genetic skeletal diseases. Hartley CL et al., 2013 Dec 20, Hum Mol GenetRead more
- Loss of matrilin 1 does not exacerbate the skeletal phenotype in a mouse model of multiple epiphyseal dysplasia caused by a Matn3 V194D mutation. Bell PA et al., 2012 May, Arthritis RheumRead more
- Mild myopathy is associated with COMP but not MATN3 mutations in mouse models of genetic skeletal diseases. Pirog KA et al., 2013, PLoS OneRead more
- Mouse Ovarian Cancer Models Recapitulate the Human Tumor Microenvironment and Patient Response to Treatment. Maniati E et al., 2020 Jan 14, Cell RepRead more
- Mutations in COMP cause familial carpal tunnel syndrome. Li C et al., 2020 Jul 20, Nat CommunRead more