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GTX14515 WB Image
GTX14515 WB Image
GTX14515 WB Image

COMP antibody

Research Use Only
GTX14515
GeneTex
ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Rat
Price on request
Packing Size
Large volume orders?
Order with a bulk request

Overview

  • Supplier
    GeneTex
  • Product Name
    COMP antibody
  • Delivery Days Customer
    10
  • Applications
    Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Host
    Rabbit
  • Isotype
    IgG
  • Scientific Description
    The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Contraction or expansion of a 5 aa aspartate repeat and other mutations can cause pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED). [provided by RefSeq, Jul 2016]
  • Reactivity
    Human, Mouse, Rat
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352203

References

  • A mouse model offers novel insights into the myopathy and tendinopathy often associated with pseudoachondroplasia and multiple epiphyseal dysplasia. Pirog KA et al., 2010 Jan 1, Hum Mol Genet
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  • A novel form of chondrocyte stress is triggered by a COMP mutation causing pseudoachondroplasia. Suleman F et al., 2012 Jan, Hum Mutat
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  • A novel transgenic mouse model of growth plate dysplasia reveals that decreased chondrocyte proliferation due to chronic ER stress is a key factor in reduced bone growth. Gualeni B et al., 2013 Nov, Dis Model Mech
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  • A small molecule promotes cartilage extracellular matrix generation and inhibits osteoarthritis development. Shi Y et al., 2019 Apr 23, Nat Commun
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  • Analysis of the cartilage proteome from three different mouse models of genetic skeletal diseases reveals common and discrete disease signatures. Bell PA et al., 2013 Aug 15, Biol Open
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  • Armet/Manf and Creld2 are components of a specialized ER stress response provoked by inappropriate formation of disulphide bonds: implications for genetic skeletal diseases. Hartley CL et al., 2013 Dec 20, Hum Mol Genet
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  • Loss of matrilin 1 does not exacerbate the skeletal phenotype in a mouse model of multiple epiphyseal dysplasia caused by a Matn3 V194D mutation. Bell PA et al., 2012 May, Arthritis Rheum
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  • Mild myopathy is associated with COMP but not MATN3 mutations in mouse models of genetic skeletal diseases. Pirog KA et al., 2013, PLoS One
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  • Mouse Ovarian Cancer Models Recapitulate the Human Tumor Microenvironment and Patient Response to Treatment. Maniati E et al., 2020 Jan 14, Cell Rep
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  • Mutations in COMP cause familial carpal tunnel syndrome. Li C et al., 2020 Jul 20, Nat Commun
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