Overview
- SupplierGeneTex
- Product NameCrkL antibody
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration0.33 mg/ml
- IsotypeIgG
- Scientific DescriptionThis gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- A high-throughput pipeline for validation of antibodies. Sikorski K et al., 2018 Nov, Nat MethodsRead more
- CRKL oncogene is downregulated by p53 through miR-200s. Tamura M et al., 2015 Aug, Cancer SciRead more
- miR-124-3p Suppresses the Invasiveness and Metastasis of Hepatocarcinoma Cells via Targeting CRKL. Majid A et al., 2020, Front Mol BiosciRead more
- miR-429-CRKL axis regulates clear cell renal cell carcinoma malignant progression through SOS1/MEK/ERK/MMP2/MMP9 pathway. Wang J et al., 2020 Jul, Biomed PharmacotherRead more