Cyclin D1 Antibody / CCND1
ORB385804
Overview
- SupplierBiorbyt
- Product NameCyclin D1 Antibody / CCND1
- Delivery Days Customer16
- ApplicationsFlow Cytometry
- Applications SupplierFlow Cytometry: 0.5-1ug/million cells in 0.1ml,Immunohistochemistry (FFPE): 0.5-1ug/ml for 30 min at RT (1),Prediluted IHC only format: incubate for 30 min at RT (2) FACS, IHC-P
- CertificationResearch Use Only
- Clone IDBCLD1-1
- IsotypeIgG
- Scientific DescriptionRecognizes a protein of 36kDa, identified as cyclin D1. Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t(11; 14)(q13; q32) translocation resulting in over-expression of cyclin D1. This antibody is useful in identifying mantle cell lymphomas (cyclin D1 positive) from CLL/SLL and follicular lymphomas (cyclin D1 negative). Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1.
- UNSPSC12352203