GTX129127 IHC-P Image
GTX129127 IHC-P Image
DNMT3B antibody
GTX129127
Product group Antibodies
Overview
- SupplierGeneTex
- Product NameDNMT3B antibody
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration1 mg/ml
- IsotypeIgG
- Scientific DescriptionCpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Six alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined. [provided by RefSeq]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- A Tangeretin Derivative Inhibits the Growth of Human Prostate Cancer LNCaP Cells by Epigenetically Restoring p21 Gene Expression and Inhibiting Cancer Stem-like Cell Proliferation. Wei GJ et al., 2019 Jul 10, AAPS JRead more
- Epigenetic Modification and Differentiation Induction of Malignant Glioma Cells by Oligo-Fucoidan. Liao CH et al., 2019 Sep 8, Mar DrugsRead more
- Epigenetic regulation by DNA methyltransferases during torpor in the thirteen-lined ground squirrel Ictidomys tridecemlineatus. Tessier SN et al., 2021 Nov, Mol Cell BiochemRead more
- Epigenetic targeting DNMT1 of pancreatic ductal adenocarcinoma using interstitial control release biodegrading polymer reduced tumor growth through hedgehog pathway inhibition. Huang MH et al., 2019 Jan, Pharmacol ResRead more
- Epigenetic underpinnings of freeze avoidance in the goldenrod gall moth, Epiblema scudderiana. Williamson SM et al., 2021 Oct, J Insect PhysiolRead more
- Insulin and Metformin Control Cell Proliferation by Regulating TDG-Mediated DNA Demethylation in Liver and Breast Cancer Cells. Yan JB et al., 2020 Sep 25, Mol Ther OncolyticsRead more
- Procainamide Inhibits DNA Methylation and Alleviates Multiple Organ Dysfunction in Rats with Endotoxic Shock. Shih CC et al., 2016, PLoS OneRead more
- The inhibitory activity of gallic acid against DNA methylation: application of gallic acid on epigenetic therapy of human cancers. Weng YP et al., 2018 Jan 2, OncotargetRead more
- The role of DNA methylation during anoxia tolerance in a freshwater turtle (Trachemys scripta elegans). Wijenayake S et al., 2016 Apr, J Comp Physiol BRead more
- USP7 negatively controls global DNA methylation by attenuating ubiquitinated histone-dependent DNMT1 recruitment. Li J et al., 2020, Cell DiscovRead more