Dystrophin antibody, MAb

Biorbyt

Dystrophin antibody, MAb

10

Western Blot, ImmunoHistoChemistry

Western blot - 1-2 μg/ml - Human, mouse, rabbit, rat - - - Immunohistochemistry(Paraffin-embedded Section) - 2-4 μg/ml - Human, mouse, rabbit, rat - - - By Heat WB, IHC

Research Use Only

Monoclonal

Clone: MANDYS8

500 ug/ml

Mouse

IgG2b

Mouse monoclonal antibody to DystrophinDMD gene has 79 exons spanning at least 2,300 kb 2.3 Mb. The C terminus of the dystrophin protein is encoded by a highly conserved, alternatively spliced region of the gene. beta-dystroglycan binding activity is expressed by the dystrophin fragment spanning amino acids 3026-3345 containing the ZZ domain. DMD transcript is formed by at least 60 exons; the first half of the transcript is formed by a minimum of 33 exons spanning nearly 1000 kb, and the remaining portion has at least 27 exons that may spread over a similar distance. Dystrophin gene is expressed at a higher level in primary cultures of neuronal cells than in astro-glial cells derived from adult mouse brain. overexpression of dystrophin prevents the development of the abnormal mechanical properties associated with dystrophic muscle without causing deleterious side effects.

Human, Mouse, Rabbit, Rat

2°C to 8°C,-20°C

12352203