E-Cadherin antibody
GTX100443
Product group Antibodies
Overview
- SupplierGeneTex
- Product NameE-Cadherin antibody
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration0.29 mg/ml
- IsotypeIgG
- Scientific DescriptionThis gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. [provided by RefSeq]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
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- Agonist of PPAR-gamma Reduced Epithelial-Mesenchymal Transition in Eosinophilic Chronic Rhinosinusitis with Nasal Polyps via Inhibition of High Mobility Group Box1. Yang P et al., 2019, Int J Med SciRead more
- An Effective Multi-Stage Liposomal DNA Origami Nanosystem for In Vivo Cancer Therapy. Palazzolo S et al., 2019 Dec 12, Cancers (Basel)Read more
- Anti-Tumoral Effects of a (1H-Pyrrol-1-yl)Methyl-1H-Benzoimidazole Carbamate Ester Derivative on Head and Neck Squamous Carcinoma Cell Lines. Nicolai A et al., 2021 Jun 12, Pharmaceuticals (Basel)Read more
- Aza-PBHA, a potent histone deacetylase inhibitor, inhibits human gastric-cancer cell migration via PKCalpha-mediated AHR-HDAC interactions. Tsai CH et al., 2020 Feb, Biochim Biophys Acta Mol Cell ResRead more
- Biomarker discovery in highly invasive lung cancer cell through proteomics approaches. Kuo CH et al., 2021 Apr, Cell Biochem FunctRead more
- CD63 tetraspanin is a negative driver of epithelial-to-mesenchymal transition in human melanoma cells. Lupia A et al., 2014 Dec, J Invest DermatolRead more