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GTX124178 WB Image
GTX124178 WB Image
GTX124178 WB Image

E-Cadherin antibody [N3C2], Internal

Research Use Only
GTX124178
GeneTex
Product group Antibodies
Price on request
Packing Size
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Overview

  • Supplier
    GeneTex
  • Product Name
    E-Cadherin antibody [N3C2], Internal
  • Delivery Days Customer
    9
  • Certification
    Research Use Only
  • Concentration
    0.22 mg/ml
  • Isotype
    IgG
  • Scientific Description
    This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. [provided by RefSeq]
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352203

References

  • Antroquinonol from Antrodia Camphorata suppresses breast tumor migration/invasion through inhibiting ERK-AP-1- and AKT-NF-kappaB-dependent MMP-9 and epithelial-mesenchymal transition expressions. Lee WT et al., 2015 Apr, Food Chem Toxicol
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  • Elevation of YAP promotes the epithelial-mesenchymal transition and tumor aggressiveness in colorectal cancer. Ling HH et al., 2017 Jan 1, Exp Cell Res
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  • Overexpression of UTX promotes tumor progression in Oral tongue squamous cell carcinoma patients receiving surgical resection: a case control study. Chen YH et al., 2021 Sep 1, BMC Cancer
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