Bio-Connect
GTX633631 WB Image
GTX633631 WB Image
GTX633631 WB Image

eIF3H / EIF3S3 antibody [GT35512]

Research Use Only
GTX633631
GeneTex
Product group Antibodies
Price on request
Packing Size
Large volume orders?
Order with a bulk request

Overview

  • Supplier
    GeneTex
  • Product Name
    eIF3H / EIF3S3 antibody [GT35512]
  • Delivery Days Customer
    9
  • Certification
    Research Use Only
  • Clone ID
    GT35512
  • Concentration
    1 mg/ml
  • Isotype
    IgG
  • Scientific Description
    Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352203