GTX103977 IHC-P Image
GTX103977 IHC-P Image
EIF4E2 antibody [N1C3]
GTX103977
Product group Antibodies
Overview
- SupplierGeneTex
- Product NameEIF4E2 antibody [N1C3]
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration0.27 mg/ml
- IsotypeIgG
- Scientific DescriptionRecognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian development. Morita M et al., 2012 Sep, Mol Cell BiolRead more
- A threonyl-tRNA synthetase-mediated translation initiation machinery. Jeong SJ et al., 2019 Mar 22, Nat CommunRead more
- Cancer cells exploit eIF4E2-directed synthesis of hypoxia response proteins to drive tumor progression. Uniacke J et al., 2014 Mar 1, Cancer ResRead more
- Cap-binding protein 4EHP effects translation silencing by microRNAs. Chapat C et al., 2017 May 23, Proc Natl Acad Sci U S ARead more
- Human Cells Cultured under Physiological Oxygen Utilize Two Cap-binding Proteins to recruit Distinct mRNAs for Translation. Timpano S et al., 2016 May 13, J Biol ChemRead more
- Hypoxia activates cadherin-22 synthesis via eIF4E2 to drive cancer cell migration, invasion and adhesion. Kelly NJ et al., 2018 Feb 1, OncogeneRead more
- Hypoxia-mediated translational activation of ITGB3 in breast cancer cells enhances TGF-beta signaling and malignant features in vitro and in vivo. Sese M et al., 2017 Dec 29, OncotargetRead more
- Recruitment of the 4EHP-GYF2 cap-binding complex to tetraproline motifs of tristetraprolin promotes repression and degradation of mRNAs with AU-rich elements. Fu R et al., 2016 Mar, RNARead more
- Ribosome collisions trigger cis-acting feedback inhibition of translation initiation. Juszkiewicz S et al., 2020 Jul 13, ElifeRead more
- The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs. Garzia A et al., 2017 Jul 7, Nat CommunRead more