ENaC Beta antibody, PAb (ATTO-390)
ORB152724
ApplicationsImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry
Product group Antibodies
ReactivityHamster, Human, Mouse, Rat, Xenopus
Overview
- SupplierBiorbyt
- Product NameENaC Beta antibody, PAb (ATTO-390)
- Delivery Days Customer10
- ApplicationsImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry
- Applications SupplierWB (1:1000), IHC (1:100) ICC, IP, WB, IHC
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration1 mg/ml
- ConjugateAtto 390
- HostRabbit
- Scientific DescriptionRabbit polyclonal to ENaC Beta (ATTO-390). The Epithelial Sodium Channel (ENaC) is a membrane ion channel permeable to Na+ ions. It is located in the apical plasma membrane of epithelia in the kidneys, lung, colon, and other tissues where it plays a role in trans epithelial Na+-ion transport. Specifically Na+ transport via ENaC occurs across many epithelial surfaces, and plays a key role in regulating salt and water absorption. ENaCs are composed of three structurally related subunits that form a tetrameric channel, alpha, beta , and gamma. The expression of its alpha and beta subunits is enhanced as keratinocytes differentiate. The beta and gamma-ENaC subunits are essential for edema fluid to exert its maximal effect on net fluid absorption by distal lung epithelia(5). And it has been concluded that the subunits are differentially expressed in the retina of mice with ocular hypertension, therefore the up-regulation of alpha-ENaC proteins could serve as a protection mechanism against elevated intraocular pressure..
- ReactivityHamster, Human, Mouse, Rat, Xenopus
- Storage Instruction2°C to 8°C
- UNSPSC12352203