EPHA5 Antibody

Catalog number: MBS9601405_0,1ml
Brand: MyBioSource
Packing: 0,1 ml
Other sizes: Other sizes available, please contact us.
Price: € 308.00
Expected delivery time: 21 days
Quantity:
Western Blot (WB)
Western blot analysis of EPHA5 expr...

Product specifications for - EPHA5 Antibody

Overview: 
Product group: Antibodies
Category: Primary Antibodies
Application: Western Blot (WB), ELISA (EIA)
Application note: WB: 1:500-1:2000
Species: Human, Mouse, Rat
Host: Rabbit
Target: EPHA5
Target description: EPH receptor A5
Clonality: Polyclonal
Isotype: IgG
Properties: 
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352203
Concentration: 1 mg/ml
Form supplied: Liquid Phosphate buffered saline, pH 7,4, 150mM NaCl, 0,02% sodium azide and 50% glycerol
Storage instructions: Store at -20°C. Stable for 12 months from date of receipt.
Scientific information: 
Scientific info: Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino-hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. In addition to its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion (By similarity).Subunit Structure: Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses (By similarity).Post-translational Modifications: Phosphorylated. Phosphorylation is stimulated by the ligand EFNA5. Dephosphorylation upon stimulation by glucose, inhibits EPHA5 forward signaling and results in insulin secretion (By similarity).Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
Gene ID: 2044
Swiss prot ID: P54756
Additional information: 
Synonyms: CEK7; EHK-1; EHK1; EK7; HEK7; TYRO4; ephrin type-A receptor 5; EPH homology kinase 1; EPH-like kinase 7; brain-specific kinase; receptor protein-tyrosine kinase HEK7; tyrosine-protein kinase receptor EHK-1