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Episialin antibody, MAb

Research Use Only
ORB18216
Biorbyt
ApplicationsImmunoHistoChemistry
Product group Antibodies
ReactivityHuman
Price on request
Packing Size
Large volume orders?
Order with a bulk request

Overview

  • Supplier
    Biorbyt
  • Product Name
    Episialin antibody, MAb
  • Delivery Days Customer
    10
  • Applications
    ImmunoHistoChemistry
  • Applications Supplier
    Immunohistochemistry(Paraffin-embedded Section) - 2-4 μg/ml - Human - - - By Heat Immunohistochemistry(Frozen Section) - 2-4 μg/ml - Human - - - IHC
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    Clone: GP1.4
  • Concentration
    100 ug/ml
  • Host
    Mouse
  • Isotype
    IgG1
  • Scientific Description
    Mouse monoclonal antibody to MUC1 is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic cell lineages. It is expressed on most secretory epithelium, including mammary gland and some hematopoietic cells. It is expressed abundantly in lactating mammary glands and overexpressed abundantly inGreater than 90% breast carcinomas and metastases. Transgenic MUC1 has been shown to associate with all four cebB receptors and localize with erbB1 EGFR in lactating glands. The MUC1 gene contains seven exons and produces several different alternatively spliced variants. The major expressed form of MUC1 uses all seven exons and is a type 1 transmembrane protein with a large extracellular tandem repeat domain. The tandem repeat domain is highly O glycosylated and alterations in glycosylation have been shown in epithelial cancer cells.
  • Reactivity
    Human
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352203