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ProductsBack/ERR alpha antibody [N1], N-term
GTX108166 WB Image
GTX108166 WB Image
GTX108166 WB Image

ERR alpha antibody [N1], N-term

Research Use Only
GTX108166
GeneTex
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Product group Antibodies
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Overview

  • Supplier
    GeneTex
  • Product Name
    ERR alpha antibody [N1], N-term
  • Delivery Days Customer
    9
  • Certification
    Research Use Only
  • Concentration
    0.7 mg/ml
  • Isotype
    IgG
  • Scientific Description
    The protein encoded by this gene is a nuclear receptor that is closely related to the estrogen receptor. This protein acts as a site-specific transcription regulator and has been also shown to interact with estrogen and the transcripton factor TFIIB by direct protein-protein contact. The binding and regulatory activities of this protein have been demonstrated in the regulation of a variety of genes including lactoferrin, osteopontin, medium-chain acyl coenzyme A dehydrogenase (MCAD) and thyroid hormone receptor genes. A processed pseudogene of ESRRA is located on chromosome 13q12.1. [provided by RefSeq]
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352203

References

  • ERRalpha induces H3K9 demethylation by LSD1 to promote cell invasion. Carnesecchi J et al., 2017 Apr 11, Proc Natl Acad Sci U S A
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  • ERRalpha Maintains Mitochondrial Oxidative Metabolism and Constitutes an Actionable Target in PGC1alpha-Elevated Melanomas. Luo C et al., 2017 Oct, Mol Cancer Res
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  • ERRalpha protein is stabilized by LSD1 in a demethylation-independent manner. Carnesecchi J et al., 2017, PLoS One
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  • Estrogen Receptor alpha (ERalpha) and Estrogen Related Receptor alpha (ERRalpha) are both transcriptional regulators of the Runx2-I isoform. Kammerer M et al., 2013 Apr 30, Mol Cell Endocrinol
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  • Estrogen-related receptor alpha decreases RHOA stability to induce orientated cell migration. Sailland J et al., 2014 Oct 21, Proc Natl Acad Sci U S A
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  • Estrogen-related receptor alpha is essential for maintaining mitochondrial integrity in cisplatin-induced acute kidney injury. Tsushida K et al., 2018 Apr 15, Biochem Biophys Res Commun
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  • Estrogens induce rapid cytoskeleton re-organization in human dermal fibroblasts via the non-classical receptor GPR30. Carnesecchi J et al., 2015, PLoS One
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  • miR-135a Inhibits the Invasion of Cancer Cells via Suppression of ERRalpha. Tribollet V et al., 2016, PLoS One
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  • Regulation of glycolysis and the Warburg effect by estrogen-related receptors. Cai Q et al., 2013 Apr 18, Oncogene
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