Overview
- SupplierGeneTex
- Product NameERR alpha antibody [N1], N-term
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration0.7 mg/ml
- IsotypeIgG
- Scientific DescriptionThe protein encoded by this gene is a nuclear receptor that is closely related to the estrogen receptor. This protein acts as a site-specific transcription regulator and has been also shown to interact with estrogen and the transcripton factor TFIIB by direct protein-protein contact. The binding and regulatory activities of this protein have been demonstrated in the regulation of a variety of genes including lactoferrin, osteopontin, medium-chain acyl coenzyme A dehydrogenase (MCAD) and thyroid hormone receptor genes. A processed pseudogene of ESRRA is located on chromosome 13q12.1. [provided by RefSeq]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- ERRalpha induces H3K9 demethylation by LSD1 to promote cell invasion. Carnesecchi J et al., 2017 Apr 11, Proc Natl Acad Sci U S ARead more
- ERRalpha Maintains Mitochondrial Oxidative Metabolism and Constitutes an Actionable Target in PGC1alpha-Elevated Melanomas. Luo C et al., 2017 Oct, Mol Cancer ResRead more
- ERRalpha protein is stabilized by LSD1 in a demethylation-independent manner. Carnesecchi J et al., 2017, PLoS OneRead more
- Estrogen Receptor alpha (ERalpha) and Estrogen Related Receptor alpha (ERRalpha) are both transcriptional regulators of the Runx2-I isoform. Kammerer M et al., 2013 Apr 30, Mol Cell EndocrinolRead more
- Estrogen-related receptor alpha decreases RHOA stability to induce orientated cell migration. Sailland J et al., 2014 Oct 21, Proc Natl Acad Sci U S ARead more
- Estrogen-related receptor alpha is essential for maintaining mitochondrial integrity in cisplatin-induced acute kidney injury. Tsushida K et al., 2018 Apr 15, Biochem Biophys Res CommunRead more
- Estrogens induce rapid cytoskeleton re-organization in human dermal fibroblasts via the non-classical receptor GPR30. Carnesecchi J et al., 2015, PLoS OneRead more
- miR-135a Inhibits the Invasion of Cancer Cells via Suppression of ERRalpha. Tribollet V et al., 2016, PLoS OneRead more
- Regulation of glycolysis and the Warburg effect by estrogen-related receptors. Cai Q et al., 2013 Apr 18, OncogeneRead more