GTX70171 WB Image
GTX70171 WB Image
Estrogen Receptor alpha antibody [1F3] - Comparison, Overexpression Validated
GTX70171
ApplicationsFlow Cytometry, ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen
Product group Antibodies
ReactivityHuman, Rabbit
Overview
- SupplierGeneTex
- Product NameEstrogen Receptor alpha antibody [1F3] - Comparison, Overexpression Validated
- Delivery Days Customer10
- ApplicationsFlow Cytometry, ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID1F3
- Concentration1.56 mg/ml
- HostMouse
- IsotypeIgG
- Scientific DescriptionThis gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Mar 2014]
- ReactivityHuman, Rabbit
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- ACK1 tyrosine kinase interacts with histone demethylase KDM3A to regulate the mammary tumor oncogene HOXA1. Mahajan K et al., 2014 Oct 10, J Biol ChemRead more
- Activity and intracellular location of estrogen receptors alpha and beta in human bronchial epithelial cells. Ivanova MM et al., 2009 Jun 16, Mol Cell EndocrinolRead more
- AMPK Activation and Metabolic Reprogramming by Tamoxifen through Estrogen Receptor-Independent Mechanisms Suggests New Uses for This Therapeutic Modality in Cancer Treatment. Daurio NA et al., 2016 Jun 1, Cancer ResRead more
- Estrogen and phytoestrogen predispose to erectile dysfunction: do ER-alpha and ER-beta in the cavernosum play a role? Srilatha B et al., 2004 Feb, UrologyRead more
- Tamoxifen Rechallenge Decreases Metastatic Potential but Increases Cell Viability and Clonogenicity in a Tamoxifen-Mediated Cytotoxicity-Resistant Subline of Human Breast MCF7 Cancer Cells. Chang YC et al., 2020, Front Cell Dev BiolRead more
- Targeting claudin-3 suppresses stem cell-like phenotype in nonsquamous non-small-cell lung carcinoma. Ma L et al., 2019 Feb, Lung Cancer ManagRead more