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GTX103570 WB Image
GTX103570 WB Image
GTX103570 WB Image

Factor B antibody [N2C2], Internal

Research Use Only
GTX103570
GeneTex
Product group Antibodies
Price on request
Packing Size
Large volume orders?
Order with a bulk request

Overview

  • Supplier
    GeneTex
  • Product Name
    Factor B antibody [N2C2], Internal
  • Delivery Days Customer
    9
  • Certification
    Research Use Only
  • Concentration
    0.87 mg/ml
  • Isotype
    IgG
  • Scientific Description
    This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5 end of the gene for complement component 2. [provided by RefSeq]
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352203

References

  • Evaluation of differential serum expression of three factors and pulmonary function in patients with silicosis. Zhu Y et al., 2021 Aug 5, Int J Occup Med Environ Health
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  • Protein Expression Profile in Rat Silicosis Model Reveals Upregulation of PTPN2 and Its Inhibitory Effect on Epithelial-Mesenchymal Transition by Dephosphorylation of STAT3. Zhu Y et al., 2020 Feb 11, Int J Mol Sci
    Read more