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GTX110300 WB Image
GTX110300 WB Image
GTX110300 WB Image

Factor X antibody

Research Use Only
GTX110300
GeneTex
Product group Antibodies
Price on request
Packing Size
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Overview

  • Supplier
    GeneTex
  • Product Name
    Factor X antibody
  • Delivery Days Customer
    9
  • Certification
    Research Use Only
  • Concentration
    1.05 mg/ml
  • Isotype
    IgG
  • Scientific Description
    This gene encodes the vitamin K-dependent coagulation factor X of the blood coagulation cascade. This factor undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity. [provided by RefSeq]
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352203

References

  • A hexon-specific PEGylated adenovirus vector utilizing blood coagulation factor X. Matsui H et al., 2012 May, Biomaterials
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  • A plasma proteolysis pathway comprising blood coagulation proteases. Yang L et al., 2016 Jul 5, Oncotarget
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  • Anticoagulants inhibit proteolytic clearance of plasma amyloid beta. Yang L et al., 2018 Jan 19, Oncotarget
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