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ProductsBack/FANCD2 antibody
GTX30142 WB Image
GTX30142 WB Image
GTX30142 WB Image

FANCD2 antibody

Research Use Only
GTX30142
GeneTex
ApplicationsFlow Cytometry, ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
DownloadDatasheet
Product group Antibodies
ReactivityCanine, Human, Mouse, Primate
Price on request
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More than 130 suppliers
ISO certified
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Overview

  • Supplier
    GeneTex
  • Product Name
    FANCD2 antibody
  • Delivery Days Customer
    10
  • Applications
    Flow Cytometry, ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1 mg/ml
  • Host
    Rabbit
  • Isotype
    IgG
  • Scientific Description
    The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group D2. This protein is monoubiquinated in response to DNA damage, resulting in its localization to nuclear foci with other proteins (BRCA1 AND BRCA2) involved in homology-directed DNA repair. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq]
  • Reactivity
    Canine, Human, Mouse, Primate
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352203

References

  • Cisplatin-induced DNA damage activates replication checkpoint signaling components that differentially affect tumor cell survival. Wagner JM et al., 2009 Jul, Mol Pharmacol
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  • Diagnosis of Fanconi anemia in children with atypical clinical features: a primary study. Liu R et al., 2013 Dec, Chin Med J (Engl)
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  • Differential roles for DNA polymerases eta, zeta, and REV1 in lesion bypass of intrastrand versus interstrand DNA cross-links. Hicks JK et al., 2010 Mar, Mol Cell Biol
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  • Genomically Incorporated 5-Fluorouracil that Escapes UNG-Initiated Base Excision Repair Blocks DNA Replication and Activates Homologous Recombination. Huehls AM et al., 2016 Jan, Mol Pharmacol
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  • Homologous recombination is a primary pathway to repair DNA double-strand breaks generated during DNA rereplication. Truong LN et al., 2014 Oct 17, J Biol Chem
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  • HPV-16 E7 reveals a link between DNA replication stress, fanconi anemia D2 protein, and alternative lengthening of telomere-associated promyelocytic leukemia bodies. Spardy N et al., 2008 Dec 1, Cancer Res
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  • Multiple DNA damage signaling and repair pathways deregulated by simian virus 40 large T antigen. Boichuk S et al., 2010 Aug, J Virol
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  • RAD18-mediated ubiquitination of PCNA activates the Fanconi anemia DNA repair network. Geng L et al., 2010 Oct 18, J Cell Biol
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  • The BRCA1-interacting protein Abraxas is required for genomic stability and tumor suppression. Castillo A et al., 2014 Aug 7, Cell Rep
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  • The human papillomavirus type 16 E7 oncoprotein activates the Fanconi anemia (FA) pathway and causes accelerated chromosomal instability in FA cells. Spardy N et al., 2007 Dec, J Virol
    Read more