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GTX116024 WB Image
GTX116024 WB Image
GTX116024 WB Image

Fas antibody [N3C2], Internal

Research Use Only
GTX116024
GeneTex
Product group Antibodies
Price on request
Packing Size
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Order with a bulk request

Overview

  • Supplier
    GeneTex
  • Product Name
    Fas antibody [N3C2], Internal
  • Delivery Days Customer
    9
  • Certification
    Research Use Only
  • Concentration
    0.7 mg/ml
  • Isotype
    IgG
  • Scientific Description
    The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. At least eight alternatively spliced transcript variants encoding seven distinct isoforms have been described. The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. [provided by RefSeq]
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352203

References

  • A Fas Ligand (FasL)-Fused Humanized Antibody Against Tumor-Associated Glycoprotein 72 Selectively Exhibits the Cytotoxic Effect Against Oral Cancer Cells with a Low FasL/Fas Ratio. Chien MH et al., 2017 Jun, Mol Cancer Ther
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