GTX13549 WB Image
Fas antibody [ZB4]
GTX13549
ApplicationsFlow Cytometry, Western Blot, ImmunoHistoChemistry, Neutralisation/Blocking, Other Application
Product group Antibodies
ReactivityHuman
Overview
- SupplierGeneTex
- Product NameFas antibody [ZB4]
- Delivery Days Customer10
- ApplicationsFlow Cytometry, Western Blot, ImmunoHistoChemistry, Neutralisation/Blocking, Other Application
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDZB4
- Concentration1 mg/ml
- HostMouse
- IsotypeIgG
- Scientific DescriptionThe protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. [provided by RefSeq, Mar 2011]
- ReactivityHuman
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- Fas/FasL interaction mediates imbalanced cytokine/cytotoxicity responses of iNKT cells against Jurkat cells. Dou R et al., 2018 Jul, Mol ImmunolRead more
- Huachansu suppresses human bladder cancer cell growth through the Fas/Fasl and TNF- alpha/TNFR1 pathway in vitro and in vivo. Yang T et al., 2015 Feb 25, J Exp Clin Cancer ResRead more
- Mechanisms of resveratrol-induced platelet apoptosis. Lin KH et al., 2009 Aug 1, Cardiovasc ResRead more
- Rabbit antithymocyte globulin induces human lymphocyte activation, proliferation, and apoptosis in the absence of complement: an experimental study. Tan X et al., 2021 May, Transpl IntRead more
- Tat-induced FOXO3a is a key mediator of apoptosis in HIV-1-infected human CD4+ T lymphocytes. Dabrowska A et al., 2008 Dec 15, J ImmunolRead more