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GTX13549 WB Image
GTX13549 WB Image
GTX13549 WB Image

Fas antibody [ZB4]

Research Use Only
GTX13549
GeneTex
ApplicationsFlow Cytometry, Western Blot, ImmunoHistoChemistry, Neutralisation/Blocking, Other Application
Product group Antibodies
ReactivityHuman
Price on request
Packing Size
Large volume orders?
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Overview

  • Supplier
    GeneTex
  • Product Name
    Fas antibody [ZB4]
  • Delivery Days Customer
    10
  • Applications
    Flow Cytometry, Western Blot, ImmunoHistoChemistry, Neutralisation/Blocking, Other Application
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    ZB4
  • Concentration
    1 mg/ml
  • Host
    Mouse
  • Isotype
    IgG
  • Scientific Description
    The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. [provided by RefSeq, Mar 2011]
  • Reactivity
    Human
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352203

References

  • Fas/FasL interaction mediates imbalanced cytokine/cytotoxicity responses of iNKT cells against Jurkat cells. Dou R et al., 2018 Jul, Mol Immunol
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  • Huachansu suppresses human bladder cancer cell growth through the Fas/Fasl and TNF- alpha/TNFR1 pathway in vitro and in vivo. Yang T et al., 2015 Feb 25, J Exp Clin Cancer Res
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  • Mechanisms of resveratrol-induced platelet apoptosis. Lin KH et al., 2009 Aug 1, Cardiovasc Res
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  • Rabbit antithymocyte globulin induces human lymphocyte activation, proliferation, and apoptosis in the absence of complement: an experimental study. Tan X et al., 2021 May, Transpl Int
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  • Tat-induced FOXO3a is a key mediator of apoptosis in HIV-1-infected human CD4+ T lymphocytes. Dabrowska A et al., 2008 Dec 15, J Immunol
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