FER antibody, PAb

Biorbyt

FER antibody, PAb

16

Western Blot, ImmunoHistoChemistry

Western blot - 0.1-0.5 μg/ml - Human, Rat - - - Immunohistochemistry(Paraffin-embedded Section) - 0.5-1 μg/ml - Human, Rat - - - By Heat WB, IHC

Research Use Only

Polyclonal

500 ug/ml

Rabbit

IgG

Rabbit Polyclonal to FER. FER(FPS/FES-Related tyrosine kinase) also known as TYK3, is an enzyme that in humans is encoded by the FER gene. Fer protein is a member of the FPS/FES family of nontransmembrane receptor tyrosine kinases. By in situ hybridization, Morris et al. (1990) concluded that the FER gene is located at 5q21-q22. Treatment of cells with JMP resulted in the release of FER from the cadherin complex and its accumulation in the integrin complex. The accumulation of FER in the integrin complex and the inhibitory effects of JMP could be reversed with a peptide that mimics the first coiled-coil domain of FER. The results suggested that FER mediates crosstalk between CDH2 and ITGB1. In Fer mutant mice, leukocyte emigration was exaggerated in response to LPS without altering vascular permeability, suggesting that FER has a role in regulating innate immunity.

Chicken, Human, Rat

2°C to 8°C,-20°C

12352203