Bio-Connect

FGF21 antibody, PAb

Research Use Only
ORB27781
Biorbyt
ApplicationsWestern Blot, ELISA
Product group Antibodies
ReactivityMouse
Price on request
Packing Size
Large volume orders?
Order with a bulk request

Overview

  • Supplier
    Biorbyt
  • Product Name
    FGF21 antibody, PAb
  • Delivery Days Customer
    10
  • Applications
    Western Blot, ELISA
  • Applications Supplier
    ELISA, WB
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Conjugate
    Unconjugated
  • Host
    Rabbit
  • Isotype
    IgG
  • Scientific Description
    Fibroblast growth factor 21(FGF21) is a novel protein that has been implicated in the regulation of lipid and glucose metabolism under fasting and ketotic conditions. In murine models, FGF21 is predominantly expressed in liver, but it also expressed in adipose tissue and pancreatic beta-cells. FGF21 stimulates glucose uptake in adipocytes. It also protects animals from diet-induced obesity when overexpressed in transgenic mice and lowers blood glucose and triglyceride levels when administered to diabetic rodents. When administered daily for 6 weeks to diabetic rhesus monkeys, FGF21 caused a dramatic decline in fasting plasma glucose, fructosamine, triglycerides, insulin, and glucagon. Furthermore, elevated plasma FGF21 concentrations in humans appear to be related to the presence of hepatic and peripheral insulin resistance.
  • Source
    This antibody can be used at 0.2microg/mL - 0.5microg/mL with the appropriate secondary reagents to detect mouse FGF21.
  • Reactivity
    Mouse
  • UNSPSC
    12352203