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GTX37695 IHC-P Image
GTX37695 IHC-P Image
GTX37695 IHC-P Image

Filaggrin antibody

Research Use Only
GTX37695
GeneTex
ApplicationsImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
DownloadDatasheet
Product group Antibodies
ReactivityHuman, Mouse, Rat
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Packing Size
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More than 130 suppliers
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Overview

  • Supplier
    GeneTex
  • Product Name
    Filaggrin antibody
  • Delivery Days Customer
    10
  • Applications
    ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.5 mg/ml
  • Host
    Rabbit
  • Isotype
    IgG
  • Scientific Description
    The protein encoded by this gene is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Mutations in this gene are associated with ichthyosis vulgaris.[provided by RefSeq, Dec 2009]
  • Reactivity
    Human, Mouse, Rat
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352203

References

  • Borage oil restores acidic skin pH by up-regulating the activity or expression of filaggrin and enzymes involved in epidermal lactate, free fatty acid, and acidic free amino acid metabolism in essential fatty acid-deficient Guinea pigs. Kim KP et al., 2018 Oct, Nutr Res
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  • Chondroitin 6-sulfate represses keratinocyte proliferation in mouse skin, which is associated with psoriasis. Kitazawa K et al., 2021 Jan 25, Commun Biol
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  • Effects of chloroform fraction of Fritillariae Thunbergii Bulbus on atopic symptoms in a DNCB-induced atopic dermatitis-like skin lesion model and in vitro models. Kim EY et al., 2021 Dec 5, J Ethnopharmacol
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  • Evidence for the critical role of the PI3K signaling pathway in particulate matter-induced dysregulation of the inflammatory mediators COX-2/PGE2 and the associated epithelial barrier protein Filaggrin in the bronchial epithelium. Song C et al., 2020 Aug, Cell Biol Toxicol
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  • Fermented Morinda citrifolia (Noni) Alleviates DNCB-Induced Atopic Dermatitis in NC/Nga Mice through Modulating Immune Balance and Skin Barrier Function. Kim SH et al., 2020 Jan 18, Nutrients
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  • Glycofullerenes Inhibit Particulate Matter Induced Inflammation and Loss of Barrier Proteins in HaCaT Human Keratinocytes. Lee CW et al., 2020 Mar 28, Biomolecules
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  • Myosin X is recruited to nascent focal adhesions at the leading edge and induces multi-cycle filopodial elongation. He K et al., 2017 Oct 20, Sci Rep
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  • PAX9 regulates squamous cell differentiation and carcinogenesis in the oro-oesophageal epithelium. Xiong Z et al., 2018 Feb, J Pathol
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  • Water-Soluble Fullerenol C60(OH)36 toward Effective Anti-Air Pollution Induced by Urban Particulate Matter in HaCaT Cell. Lee CW et al., 2019 Aug 30, Int J Mol Sci
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