FKBP51 antibody, MAb (HRP)
ORB147196
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry
Product group Antibodies
ReactivityCanine, Hamster, Human, Mouse, Rabbit, Rat
Overview
- SupplierBiorbyt
- Product NameFKBP51 antibody, MAb (HRP)
- Delivery Days Customer10
- ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry
- Applications SupplierWB (1:2000), ICC/IF (1:1000) ICC, WB
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDHi51B
- Concentration1 mg/ml
- ConjugateHRP
- HostMouse
- IsotypeIgG1
- Scientific DescriptionMouse monoclonal to FKBP51 (HRP). Hsp90 is crucial to cellular signaling by its regulation of the folding, activity, and stability of a wide range of client proteins. These client protein complexes may also contain one or more cochaperones. One class of Hsp90-binding cochaperone is composed of proteins with a characteristic tetratricopeptide repeat (TPR) domain that forms an Hsp90 binding site. Among the TPR cochaperones of Hsp90 are Hop/Sti1, protein phosphatase PP5, and members of both the FK506- and cyclosporin A-binding families of immunophilins. FK506-binding protein 51 (FKBP51) and FKBP52 are large molecular weight immunophilins that are part of the mature glucocorticoid receptor (GR) heterocomplex. The N terminal domain of each protein binds FK506 and has peptidyl-prolyl isomerase (PPIase) activity that converts prolyl peptide bonds within target proteins from cis- to trans- proline. The C-terminal domains contain the TPR repeats involved in protein-protein interactions with the Hsp90. Although FKBP52 and FKBP51 share 75% sequence similarity, they affect hormone binding by glucocorticoid receptor in opposing manners and have different Hsp90-binding characteristics. FK506 binding protein 51 kDa (FKBP51 or otherwise referred to as FKBP54) has been identified as a progestininducible gene. This protein is predominantly expressed in murine T cells but in humans, it is abundantly expressed in numerous tissues at levels many times higher than FKBP12. The FKBP51 gene is known to be induced by glucocorticoids..
- ReactivityCanine, Hamster, Human, Mouse, Rabbit, Rat
- Storage Instruction2°C to 8°C
- UNSPSC12352203