Overview
- SupplierGeneTex
- Product NameFZR1 antibody
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration0.26 mg/ml
- IsotypeIgG
- Scientific DescriptionKey regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis.
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- CCDC84 Acetylation Oscillation Regulates Centrosome Duplication by Modulating HsSAS-6 Degradation. Wang T et al., 2019 Nov 12, Cell RepRead more