Overview
- SupplierGeneTex
- Product NameGAD67 antibody
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration0.57 mg/ml
- IsotypeIgG
- Scientific DescriptionThis gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form. [provided by RefSeq]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- ACE2 modulates glucose homeostasis through GABA signaling during metabolic stress. Ma X et al., 2020 Sep, J EndocrinolRead more
- Age-related Changes in Auditory Cortex Without Detectable Peripheral Alterations: A Multi-level Study in Sprague-Dawley Rats. Occelli F et al., 2019 Apr 15, NeuroscienceRead more
- Loss of phenotype of parvalbumin interneurons in rat prefrontal cortex is involved in antidepressant- and propsychotic-like behaviors following acute and repeated ketamine administration. Zhou Z et al., 2015 Apr, Mol NeurobiolRead more
- Neural network disturbance in the medial prefrontal cortex might contribute to cognitive impairments induced by neuroinflammation. Ji MH et al., 2020 Oct, Brain Behav ImmunRead more
- Two Groups of eGFP-Expressing Neurons with Distinct Characteristics in the Neocortex of GIN Mice. Wang C et al., 2019 Apr 15, NeuroscienceRead more