GTX109121 WB Image
GTX109121 WB Image
Glutamine synthetase antibody
GTX109121
Product group Antibodies
Overview
- SupplierGeneTex
- Product NameGlutamine synthetase antibody
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration1 mg/ml
- IsotypeIgG
- Scientific DescriptionGlutamine is a main source of energy and is involved in cell proliferation, inhibition of apoptosis, and cell signaling (Haberle et al., 2005 [PubMed 16267323]). Fetal glutamine requirements are very high and depend largely on active glutamine synthesis and the release of glutamine into the fetal circulation by the placenta. Glutamine synthetase (EC 6.3.1.2), also called glutamate-ammonia ligase (GLUL), is expressed throughout the body and plays an important role in controlling body pH and in removing ammonia from the circulation. The enzyme clears L-glutamate, the major neurotransmitter in the central nervous system, from neuronal synapses (see references in Clancy et al., 1996 [PubMed 8975719]).[supplied by OMIM]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- A spatial similarity of stereochemical environments formed by amino acid residues defines a common epitope of two non-homologous proteins. Nakashima K et al., 2019 Oct 15, Sci RepRead more
- Cancer Cachexia Induces Preferential Skeletal Muscle Myosin Loss When Combined With Denervation. Yamada T et al., 2020, Front PhysiolRead more
- FOXO1 activates glutamine synthetase gene in mouse skeletal muscles through a region downstream of 3-UTR: possible contribution to ammonia detoxification. Kamei Y et al., 2014 Sep 15, Am J Physiol Endocrinol MetabRead more
- Hepatoblastoma: glutamine depletion hinders cell viability in the embryonal subtype but high GLUL expression is associated with better overall survival. Schmidt A et al., 2021 Nov, J Cancer Res Clin OncolRead more
- Inflammasome Activation Induces Pyroptosis in the Retina Exposed to Ocular Hypertension Injury. Pronin A et al., 2019, Front Mol NeurosciRead more
- Lithium and glutamine synthetase: Protective effects following stress. Mundorf A et al., 2019 Nov, Psychiatry ResRead more