Granzyme B Antibody
ORB317047
Overview
- SupplierBiorbyt
- Product NameGranzyme B Antibody
- Delivery Days Customer16
- ApplicationsFlow Cytometry
- Applications SupplierFlow Cytometry: 0.5-1ug/million cells in 0.1ml,Immunofluorescence: 0.5-1ug/ml,Western blot: 1-2ug/ml,Immunohistochemistry (FFPE): 0.5-1ug/ml for 30 min at RT (1) FACS, IF, IHC-P, WB
- CertificationResearch Use Only
- IsotypeIgG
- Scientific DescriptionGranzyme B is a member of the granule serine protease family stored specifically in NK cells or cytotoxic T cells. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface non-self antigens, usually peptides or proteins resulting from infection by intracellular pathogens. Granzyme B is crucial for the rapid induction of target cell apoptosis by CTLs in the cell-mediated immune response. Granzyme B is useful as a marker in the identification of NK/T-cell lymphomas. High percentages of cytotoxic T-cells have been shown to be an unfavorable prognostic indicator in Hodgkins Disease.
- UNSPSC12352203