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GTX130007 WB Image
GTX130007 WB Image
GTX130007 WB Image

GRK2 (phospho Ser670) antibody

Research Use Only
GTX130007
GeneTex
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Product group Antibodies
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More than 130 suppliers
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Overview

  • Supplier
    GeneTex
  • Product Name
    GRK2 (phospho Ser670) antibody
  • Delivery Days Customer
    9
  • Certification
    Research Use Only
  • Concentration
    0.66 mg/ml
  • Isotype
    IgG
  • Scientific Description
    The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. [provided by RefSeq]
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352203

References

  • Co-treatment with clonidine and a GRK2 inhibitor prevented rebound hypertension and endothelial dysfunction after withdrawal in diabetes. Taguchi K et al., 2018 Apr, Hypertens Res
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  • LDK378 inhibits the recruitment of myeloid-derived suppressor cells to spleen via the p38-GRK2-CCR2 pathway in mice with sepsis. Hu J et al., 2019 Nov, Immunol Cell Biol
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