Overview
- SupplierGeneTex
- Product NameH-Ras antibody
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration1.95 mg/ml
- IsotypeIgG
- Scientific DescriptionThis gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene. [provided by RefSeq]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- HRAS as a potential therapeutic target of salirasib RAS inhibitor in bladder cancer. Sugita S et al., 2018 Aug, Int J OncolRead more
- Key Players of Cisplatin Resistance: Towards a Systems Pharmacology Approach. Sarin N et al., 2018 Mar 7, Int J Mol SciRead more
- MLL3 Induced by Luteolin Causes Apoptosis in Tamoxifen-Resistant Breast Cancer Cells through H3K4 Monomethylation and Suppression of the PI3K/AKT/mTOR Pathway. Wu HT et al., 2020, Am J Chin MedRead more
- Mouse genetic background influences whether HrasG12V expression plus Cdkn2a knockdown causes angiosarcoma or undifferentiated pleomorphic sarcoma. Brandt LP et al., 2018 Apr 13, OncotargetRead more
- Nogo-B receptor increases the resistance to tamoxifen in estrogen receptor-positive breast cancer cells. Gao P et al., 2018 Sep 12, Breast Cancer ResRead more
- NOGOB receptor-mediated RAS signaling pathway is a target for suppressing proliferating hemangioma. Hu W et al., 2021 Feb 8, JCI InsightRead more
- Oncogenic HrasG12V expression plus knockdown of Cdkn2a using ecotropic lentiviral vectors induces high-grade endometrial stromal sarcoma. Brandt LP et al., 2017, PLoS OneRead more
- The transcription factor HOXB7 regulates ERK kinase activity and thereby stimulates the motility and invasiveness of pancreatic cancer cells. Tsuboi M et al., 2017 Oct 27, J Biol ChemRead more