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GTX130062 WB Image
GTX130062 WB Image
GTX130062 WB Image

Hamartin / TSC1 antibody

Research Use Only
GTX130062
GeneTex
Product group Antibodies
Price on request
Packing Size
Large volume orders?
Order with a bulk request

Overview

  • Supplier
    GeneTex
  • Product Name
    Hamartin / TSC1 antibody
  • Delivery Days Customer
    9
  • Certification
    Research Use Only
  • Concentration
    1.38 mg/ml
  • Isotype
    IgG
  • Scientific Description
    This gene is a tumor suppressor gene that encodes the growth inhibitory protein hamartin. The encoded protein interacts with and stabilizes the GTPase activating protein tuberin. This hamartin-tuberin complex negatively regulates mammalian target of rapamycin complex 1 (mTORC1) signalling which is a major regulator of anabolic cell growth. This protein also functions as a co-chaperone for Hsp90 that inhibits its ATPase activity. This protein functions as a facilitator of Hsp90-mediated folding of kinase and non-kinase clients, including Tsc2 and thereby preventing their ubiquitination and proteasomal degradation. Mutations in this gene have been associated with tuberous sclerosis. [provided by RefSeq, Apr 2018]
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352203