Overview
- SupplierGeneTex
- Product NameHDAC3 antibody [C3], C-term
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration1 mg/ml
- IsotypeIgG
- Scientific DescriptionHistones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. [provided by RefSeq]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- Exercise increases the binding of MEF2A to the Cpt1b promoter in mouse skeletal muscle. Yuan H et al., 2014 Dec, Acta Physiol (Oxf)Read more
- Hydroxygenkwanin Inhibits Class I HDAC Expression and Synergistically Enhances the Antitumor Activity of Sorafenib in Liver Cancer Cells. Chen CY et al., 2020, Front OncolRead more
- Inhibition of HDAC3- and HDAC6-Promoted Survivin Expression Plays an Important Role in SAHA-Induced Autophagy and Viability Reduction in Breast Cancer Cells. Lee JY et al., 2016, Front PharmacolRead more
- NKILA lncRNA promotes tumor immune evasion by sensitizing T cells to activation-induced cell death. Huang D et al., 2018 Oct, Nat ImmunolRead more
- NudC deacetylation regulates mitotic progression. Chuang C et al., 2013, PLoS OneRead more