GTX113303 WB IP Image
GTX113303 WB IP Image
HDAC3 antibody
GTX113303
Product group Antibodies
Overview
- SupplierGeneTex
- Product NameHDAC3 antibody
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration0.32 mg/ml
- IsotypeIgG
- Scientific DescriptionHistones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. [provided by RefSeq]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- An HDAC3-PROX1 corepressor module acts on HNF4alpha to control hepatic triglycerides. Armour SM et al., 2017 Sep 15, Nat CommunRead more
- Histone deacetylase 3 prepares brown adipose tissue for acute thermogenic challenge. Emmett MJ et al., 2017 Jun 22, NatureRead more
- In cortical neurons HDAC3 activity suppresses RD4-dependent SMRT export. Soriano FX et al., 2011, PLoS OneRead more
- Medulloblastoma uses GABA transaminase to survive in the cerebrospinal fluid microenvironment and promote leptomeningeal dissemination. Martirosian V et al., 2021 Jun 29, Cell RepRead more
- MicroRNA-148b Targets the TGF-beta Pathway to Regulate Angiogenesis and Endothelial-to-Mesenchymal Transition during Skin Wound Healing. Miscianinov V et al., 2018 Aug 1, Mol TherRead more