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GTX110231 ICC/IF Image
GTX110231 ICC/IF Image
GTX110231 ICC/IF Image

HDAC4 antibody [N3C1], Internal

Research Use Only
GTX110231
GeneTex
Product group Antibodies
Price on request
Packing Size
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Overview

  • Supplier
    GeneTex
  • Product Name
    HDAC4 antibody [N3C1], Internal
  • Delivery Days Customer
    9
  • Certification
    Research Use Only
  • Concentration
    2.1 mg/ml
  • Isotype
    IgG
  • Scientific Description
    Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq]
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352203

References

  • GluN2B/CaMKII mediates CFA-induced hyperalgesia via HDAC4-modified spinal COX2 transcription. Lai CY et al., 2018 Jun, Neuropharmacology
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  • Melatonin relieves neuropathic allodynia through spinal MT2-enhanced PP2Ac and downstream HDAC4 shuttling-dependent epigenetic modification of hmgb1 transcription. Lin TB et al., 2016 Apr, J Pineal Res
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  • Modulation of Nerve Injury-induced HDAC4 Cytoplasmic Retention Contributes to Neuropathic Pain in Rats. Lin TB et al., 2015 Jul, Anesthesiology
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