HER2 Antibody / ErbB2
ORB534133
Overview
- SupplierBiorbyt
- Product NameHER2 Antibody / ErbB2
- Delivery Days Customer16
- ApplicationsImmunoHistoChemistry
- Applications SupplierImmunohistochemistry (FFPE): 1-2ug/ml IHC-P
- CertificationResearch Use Only
- Clone ID2KRI7-2
- IsotypeIgG
- Scientific DescriptionHER2/ErbB2 is a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. ErbB2 protein is over-expressed in a variety of carcinomas especially those of breast and ovary. [RefSeq]
- UNSPSC12352203