Overview
- SupplierGeneTex
- Product NameHERC5 antibody
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration3.96 mg/ml
- IsotypeIgG
- Scientific DescriptionThis gene is a member of the HERC family of ubiquitin ligases and encodes a protein with a HECT domain and five RCC1 repeats. Pro-inflammatory cytokines upregulate expression of this gene in endothelial cells. The protein localizes to the cytoplasm and perinuclear region and functions as an interferon-induced E3 protein ligase that mediates ISGylation of protein targets. The gene lies in a cluster of HERC family genes on chromosome 4. [provided by RefSeq]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- Induced TRIM21 ISGylation by IFN-beta enhances p62 ubiquitination to prevent its autophagosome targeting. Jin J et al., 2021 Jul 13, Cell Death DisRead more