GTX80694 IHC-P Image
GTX80694 IHC-P Image
Histone H2A.XS139ph (phospho Ser139) antibody [3F2] - Orthogonal Validated
GTX80694
ApplicationsFlow Cytometry, ImmunoFluorescence, Western Blot, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityBovine, Human, Mouse
Overview
- SupplierGeneTex
- Product NameHistone H2A.XS139ph (phospho Ser139) antibody [3F2] - Orthogonal Validated
- Delivery Days Customer10
- ApplicationsFlow Cytometry, ImmunoFluorescence, Western Blot, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID3F2
- Concentration1 mg/ml
- HostMouse
- IsotypeIgG
- Modification TypePhosphorylated
- Scientific DescriptionHistones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-independent histone that is a member of the histone H2A family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif. [provided by RefSeq, Oct 2015]
- ReactivityBovine, Human, Mouse
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- Curcumin causes DNA damage and affects associated protein expression in HeLa human cervical cancer cells. Shang HS et al., 2016 Oct, Oncol RepRead more
- CYT-Rx20 inhibits ovarian cancer cells in vitro and in vivo through oxidative stress-induced DNA damage and cell apoptosis. Wang YY et al., 2017 Jun, Cancer Chemother PharmacolRead more
- Direct activation of ATM by resveratrol under oxidizing conditions. Lee JH et al., 2014, PLoS OneRead more
- High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Fox JT et al., 2012 Apr 3, Proc Natl Acad Sci U S ARead more
- Histone deacetylase inhibitors selectively target homology dependent DNA repair defective cells and elevate non-homologous endjoining activity. Smith S et al., 2014, PLoS OneRead more
- Induction of reactive oxygen species by human T-cell leukemia virus type 1 tax correlates with DNA damage and expression of cellular senescence marker. Kinjo T et al., 2010 May, J VirolRead more
- Synthetic beta-nitrostyrene derivative CYT-Rx20 as inhibitor of oral cancer cell proliferation and tumor growth through glutathione suppression and reactive oxygen species induction. Wang YY et al., 2017 Jun, Head NeckRead more