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GTX60892 WB Image
GTX60892 WB Image
GTX60892 WB Image

Histone H3K27me3 (Tri-methyl Lys27) antibody [RM175]

Research Use Only
GTX60892
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ChIP Chromatin ImmunoPrecipitation, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman, Mouse
Price on request
Packing Size
Large volume orders?
Order with a bulk request

Overview

  • Supplier
    GeneTex
  • Product Name
    Histone H3K27me3 (Tri-methyl Lys27) antibody [RM175]
  • Delivery Days Customer
    10
  • Applications
    ImmunoFluorescence, Western Blot, ChIP Chromatin ImmunoPrecipitation, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    RM175
  • Host
    Rabbit
  • Isotype
    IgG
  • Modification Type
    Methylated
  • Scientific Description
    Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
  • Reactivity
    Human, Mouse
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352203

References

  • PRC1 collaborates with SMCHD1 to fold the X-chromosome and spread Xist RNA between chromosome compartments. Wang CY et al., 2019 Jul 3, Nat Commun
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  • Repeat E anchors Xist RNA to the inactive X chromosomal compartment through CDKN1A-interacting protein (CIZ1). Sunwoo H et al., 2017 Oct 3, Proc Natl Acad Sci U S A
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  • SMCHD1 Merges Chromosome Compartments and Assists Formation of Super-Structures on the Inactive X. Wang CY et al., 2018 Jul 12, Cell
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  • Xist Deletional Analysis Reveals an Interdependency between Xist RNA and Polycomb Complexes for Spreading along the Inactive X. Colognori D et al., 2019 Apr 4, Mol Cell
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  • Xist Repeats A and B Account for Two Distinct Phases of X Inactivation Establishment. Colognori D et al., 2020 Jul 6, Dev Cell
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