GTX101448 WB Image
GTX101448 WB Image
Hsp90 beta antibody
GTX101448
Product group Antibodies
Overview
- SupplierGeneTex
- Product NameHsp90 beta antibody
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration0.5 mg/ml
- IsotypeIgG
- Scientific DescriptionHSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein folding, protein degradation, and morphologic evolution. HSP90 proteins normally associate with other cochaperones and play important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress. There are 2 major cytosolic HSP90 proteins, HSP90AA1 (MIM 140571), an inducible form, and HSP90AB1, a constitutive form. Other HSP90 proteins are found in endoplasmic reticulum (HSP90B1; MIM 191175) and mitochondria (TRAP1; MIM 606219) (Chen et al., 2005 [PubMed 16269234]).[supplied by OMIM]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
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- Anti-EGFR antibody cetuximab is secreted by oral squamous cell carcinoma and alters EGF-driven mesenchymal transition. Fujiwara T et al., 2018 Sep 10, Biochem Biophys Res CommunRead more
- Carcinogenic epithelial-mesenchymal transition initiated by oral cancer exosomes is inhibited by anti-EGFR antibody cetuximab. Fujiwara T et al., 2018 Nov, Oral OncolRead more
- Cell Stress Induced Stressome Release Including Damaged Membrane Vesicles and Extracellular HSP90 by Prostate Cancer Cells. Eguchi T et al., 2020 Mar 19, CellsRead more
- Genomic analysis of DNA repair genes and androgen signaling in prostate cancer. Jividen K et al., 2018 Oct 10, BMC CancerRead more
- HSP-enriched properties of extracellular vesicles involve survival of metastatic oral cancer cells. Ono K et al., 2018 Sep, J Cell BiochemRead more
- Multiexon deletion alleles of ATF6 linked to achromatopsia. Lee EJ et al., 2020 Apr 9, JCI InsightRead more
- Mutations in the unfolded protein response regulator ATF6 cause the cone dysfunction disorder achromatopsia. Kohl S et al., 2015 Jul, Nat GenetRead more
- N-terminal functional domain of Gasdermin A3 regulates mitochondrial homeostasis via mitochondrial targeting. Lin PH et al., 2015 Jun 24, J Biomed SciRead more
- The unfolded protein response is shaped by the NMD pathway. Karam R et al., 2015 May, EMBO RepRead more