GTX114486 IHC-P Image
GTX114486 IHC-P Image
IDH3A antibody
GTX114486
Product group Antibodies
Overview
- SupplierGeneTex
- Product NameIDH3A antibody
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration0.63 mg/ml
- IsotypeIgG
- Scientific DescriptionIsocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the alpha subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. [provided by RefSeq]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- Knockdown of both mitochondrial isocitrate dehydrogenase enzymes in pancreatic beta cells inhibits insulin secretion. MacDonald MJ et al., 2013 Nov, Biochim Biophys ActaRead more
- The role of NAD(+)-dependent isocitrate dehydrogenase 3 subunit alpha in AFB1 induced liver lesion. Yang C et al., 2014 Jan 30, Toxicol LettRead more