GTX110521 WB Image
GTX110521 WB Image
IKB alpha antibody
GTX110521
Product group Antibodies
Overview
- SupplierGeneTex
- Product NameIKB alpha antibody
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration0.16 mg/ml
- IsotypeIgG
- Scientific DescriptionNFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB, MIM 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
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- Epoxyeicosatrienoic acids alleviate methionine-choline-deficient diet-induced non-alcoholic steatohepatitis in mice. Wang X et al., 2019 Sep, Scand J ImmunolRead more
- Inhibitory effect of litchi (Litchi chinensis Sonn.) flower on lipopolysaccharide-induced expression of proinflammatory mediators in RAW264.7 cells through NF-kappaB, ERK, and JAK2/STAT3 inactivation. Yang DJ et al., 2014 Apr 16, J Agric Food ChemRead more
- Mitoquinone ameliorates cigarette smoke-induced airway inflammation and mucus hypersecretion in mice. Yang D et al., 2021 Jan, Int ImmunopharmacolRead more
- Porcine Milk Exosome MiRNAs Attenuate LPS-Induced Apoptosis through Inhibiting TLR4/NF-kappaB and p53 Pathways in Intestinal Epithelial Cells. Xie MY et al., 2019 Aug 28, J Agric Food ChemRead more
- Protective Effect of Eupatilin Pretreatment Against Hepatic Ischemia-Reperfusion Injury in Mice. Lee HM et al., 2016 May, Transplant ProcRead more
- Substrate Stiffness Regulates Proinflammatory Mediator Production through TLR4 Activity in Macrophages. Previtera ML et al., 2015, PLoS OneRead more