GTX39969 WB Image
IL10 antibody [JES3-9D7] (Low endotoxin, azide free)
GTX39969
ApplicationsFlow Cytometry, Western Blot, ELISA, ImmunoHistoChemistry, Neutralisation/Blocking
Product group Antibodies
ReactivityHuman
Overview
- SupplierGeneTex
- Product NameIL10 antibody [JES3-9D7] (Low endotoxin, azide free)
- Delivery Days Customer10
- ApplicationsFlow Cytometry, Western Blot, ELISA, ImmunoHistoChemistry, Neutralisation/Blocking
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDJES3-9D7
- Concentration1 mg/ml
- HostRat
- IsotypeIgG
- Scientific DescriptionThe protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.[provided by RefSeq, May 2011]
- ReactivityHuman
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- Osteopontin: a new emerging role in psoriasis. Buommino E et al., 2009 Jul, Arch Dermatol ResRead more