GTX106408 IHC-P Image
GTX106408 IHC-P Image
Importin 7 antibody [C3], C-term
GTX106408
Product group Antibodies
Overview
- SupplierGeneTex
- Product NameImportin 7 antibody [C3], C-term
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration1 mg/ml
- IsotypeIgG
- Scientific DescriptionThe importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. Similar to importin-beta, this protein prevents the activation of Rans GTPase by RanGAP1 and inhibits nucleotide exchange on RanGTP, and also binds directly to nuclear pore complexes where it competes for binding sites with importin-beta and transportin. This protein has a Ran-dependent transport cycle and it can cross the nuclear envelope rapidly and in both directions. At least four importin beta-like transport receptors, namely importin beta itself, transportin, RanBP5 and RanBP7, directly bind and import ribosomal proteins. [provided by RefSeq]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- Akt-mediated phosphorylation increases the binding affinity of hTERT for importin alpha to promote nuclear translocation. Jeong SA et al., 2015 Jun 15, J Cell SciRead more
- Bovine ephemeral fever rhabdovirus alpha1 protein has viroporin-like properties and binds importin beta1 and importin 7. Joubert DA et al., 2014 Feb, J VirolRead more
- The p53-induced factor Ei24 inhibits nuclear import through an importin beta-binding-like domain. Lieu KG et al., 2014 May 12, J Cell BiolRead more