GTX22811 FACS Image
Importin beta 1 antibody [3E9]
GTX22811
ApplicationsFlow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, Neutralisation/Blocking
Product group Antibodies
ReactivityBovine, Canine, Human, Mouse, Porcine, Rat
Overview
- SupplierGeneTex
- Product NameImportin beta 1 antibody [3E9]
- Delivery Days Customer10
- ApplicationsFlow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, Neutralisation/Blocking
- CertificationResearch Use Only
- ClonalityMonoclonal
- Concentration1 mg/ml
- HostMouse
- IsotypeIgG
- Scientific DescriptionNucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]
- ReactivityBovine, Canine, Human, Mouse, Porcine, Rat
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- Identification and characterization of nuclear and nucleolar localization signals in 58-kDa microspherule protein (MSP58). Yang CP et al., 2015 May 16, J Biomed SciRead more
- N-terminally truncated POM121C inhibits HIV-1 replication. Saito H et al., 2017, PLoS OneRead more
- Ran-GTP Is Non-essential to Activate NuMA for Mitotic Spindle-Pole Focusing but Dynamically Polarizes HURP Near Chromosomes. Tsuchiya K et al., 2021 Jan 11, Curr BiolRead more
- RepoMan stimulates the chromosome-dependent pathway of microtubule assembly. De Munter S et al., 2020 Nov, Cell CycleRead more