GTX27842 IHC-P Image
GTX27842 IHC-P Image
Insulin antibody
GTX27842
ApplicationsImmunoFluorescence, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse
Overview
- SupplierGeneTex
- Product NameInsulin antibody
- Delivery Days Customer10
- ApplicationsImmunoFluorescence, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration0.2 mg/ml
- HostGuinea Pig
- IsotypeIgG
- Scientific DescriptionAfter removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5 region and with the IGF2 gene at the 3 region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]
- ReactivityHuman, Mouse
- Storage Instruction2°C to 8°C
- UNSPSC12352203
References
- An inhibitor of fibroblast growth factor receptor-1 (FGFR1) promotes late-stage terminal differentiation from NGN3+ pancreatic endocrine progenitors. Yamashita-Sugahara Y et al., 2016 Oct 27, Sci RepRead more
- Donor-Specific Regulatory T Cell-Mediated Immune Tolerance in an Intrahepatic Murine Allogeneic Islet Transplantation Model with Short-Term Anti-CD154 mAb Single Treatment. Lee SJ et al., 2020 Jan-Dec, Cell TransplantRead more
- Hes3 is expressed in the adult pancreatic islet and regulates gene expression, cell growth, and insulin release. Masjkur J et al., 2014 Dec 19, J Biol ChemRead more
- Human pancreatic afferent and efferent nerves: mapping and 3-D illustration of exocrine, endocrine, and adipose innervation. Chien HJ et al., 2019 Nov 1, Am J Physiol Gastrointest Liver PhysiolRead more
- Human pancreatic neuro-insular network in health and fatty infiltration. Tang SC et al., 2018 Jan, DiabetologiaRead more
- Mesenchymal stem cell therapy ameliorates diabetic hepatocyte damage in mice by inhibiting infiltration of bone marrow-derived cells. Nagaishi K et al., 2014 May, HepatologyRead more
- Pancreatic neuro-insular network in young mice revealed by 3D panoramic histology. Tang SC et al., 2018 Jan, DiabetologiaRead more
- Pancreatic prolactin receptor signaling regulates maternal glucose homeostasis. Nteeba J et al., 2019 Feb 1, J EndocrinolRead more
- PanIN-associated pericyte, glial, and islet remodeling in mice revealed by 3D pancreatic duct lesion histology. Lin PY et al., 2016 Sep 1, Am J Physiol Gastrointest Liver PhysiolRead more
- Tamoxifen-independent recombination in the RIP-CreER mouse. Liu Y et al., 2010 Oct 22, PLoS OneRead more