Interferon gamma antibody

GeneTex

Interferon gamma antibody

10

Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, Neutralisation/Blocking

Research Use Only

Polyclonal

Goat

IgG

Interferon gamma (IFNG), a type II or immune interferon, is produced primarily by T lymphocytes and natural killer cells stimulated by alloantigens, tumors, and mitogens. IFNG exerts a variety of biological effects including antiviral activity, inhibition of cell or tumor growth, and promotion of differentiation of B cells into immunoglobulin-producing cells. IFNG, originally characterized based on its antiviral activities, is a potent modulator of immune response and modifies cellular processes. It functions as an activating factor priming macrophages for non-specific tumorcidal activity. IFNG activates monocytes to exert enhanced cytotoxicity against tumor cells. It also boosts cytotoxicity of natural killer cells and stimulates T cell cytotoxicity. IFNG acts as a signal for the major histocompatibility antigen expression system. The species specificity of IFNG resides in the interaction of IFNG with its receptor. Mature IFNG exists as noncovalently linked homodimers. The N-terminal methionyl form of rat IFNG contains 135 amino acid residues and has a predicted molecular mass of approximately 15.5 kDa.

Mouse, Rat

2°C to 8°C,-20°C

12352203