The MIG-2F5.5 monoclonal antibody reacts with mouse CXCL9 also known as MIG. CXCL9 is a chemotactic cytokine that belongs to the CXC subfamily of chemokines. CXCL9 is expressed on monocytes, macrophages, hepatocytes, endothelial cells, and primary glial cells in response to IFN? stimulation. CXCL9 has been shown to be a chemoattractant for resting memory and activated CD4+ and CD8+ T cells, and NK cells expressing its receptor, CXCR3. Binding of CXCL9 to CXCR3 induces various cellular responses, including integrin activation, cytoskeletal changes and chemotactic migration.
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