IRS1 antibody, PAb

Biorbyt

IRS1 antibody, PAb

10

Western Blot

Western blot - 0.1-0.5 μg/ml - Human - Mouse, Rat - WB

Research Use Only

Polyclonal

500 ug/ml

Rabbit

IgG

Insulin receptor substrate 1 (IRS-1) is a signalling adapter protein that in humans is encoded by the IRS-1 gene. It is mapped to 2q36.3. This gene exhibited no intrinsic enzyme activity, and it can serve as a docking protein involved in binding and activating other signal transduction molecules after being phosphorylated on tyrosine by insulin receptor kinase. IRS1 plays a key role in transmitting signals from the insulin and insulin-like growth factor-1 (IGF-1) receptors to intracellular pathways PI3K / Akt and Erk MAP kinase pathways. IRS1 also plays important biological function for both metabolic and mitogenic (growth promoting) pathways. In addition to those, IRS1 is a key regulator of PI3K within malignant cells.

Hamster, Human, Mouse, Rat

2°C to 8°C,-20°C

12352203