KDM1A antibody, PAb
ORB66996
Overview
- SupplierBiorbyt
- Product NameKDM1A antibody, PAb
- Delivery Days Customer16
- ApplicationsWestern Blot
- Applications SupplierWB:1:1000-1:5000 WB
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- HostRabbit
- IsotypeIgG
- Scientific DescriptionRabbit polyclonal to KDM1A.Lysine-specific histone demethylase 1A (KDM1A) is a histone demethylase that demethylates bothLys-4 (H3K4me) and Lys-9 (H3K9me) of histone H3, thereby acting as a coactivator or acorepressor, depending on the context. KDM1A acts as a corepressor by mediating demethylation ofH3K4me, a specific tag for epigenetic transcriptional activation. KDM1A can demethylate both mono-(H3K4me1) and di-methylated (H3K4me2) H3K4me, and may play a role in the repression of neuronalgenes. KDM1A also acts as a coactivator of androgen receptor (ANDR)-dependent transcription, bybeing recruited to ANDR target genes and mediating demethylation of H3K9me, a specific tag forepigenetic transcriptional repression. KDM1A is required for gastrulation during embryogenesis.
- ReactivityHuman
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203