Overview
- SupplierGeneTex
- Product NameKu70 antibody
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration0.25 mg/ml
- IsotypeIgG
- Scientific DescriptionThe p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus. [provided by RefSeq]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
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- CD24+ tumor-initiating cells from oral squamous cell carcinoma induce initial angiogenesis in vivo. Zimmerer RM et al., 2017 Jul, Microvasc ResRead more
- Chloroquine inhibits human retina pigmented epithelial cell growth and microtubule nucleation by downregulating p150glued. Chen TY et al., 2019 Jul, J Cell PhysiolRead more
- Classical non-homologous end-joining pathway utilizes nascent RNA for error-free double-strand break repair of transcribed genes. Chakraborty A et al., 2016 Oct 5, Nat CommunRead more
- Cordycepin Inhibits Human Gestational Choriocarcinoma Cell Growth by Disrupting Centrosome Homeostasis. Wang CY et al., 2020, Drug Des Devel TherRead more
- CSL controls telomere maintenance and genome stability in human dermal fibroblasts. Bottoni G et al., 2019 Aug 29, Nat CommunRead more
- Genotoxic stress-activated DNA-PK-p53 cascade and autophagy cooperatively induce ciliogenesis to maintain the DNA damage response. Chen TY et al., 2021 Jun, Cell Death DifferRead more
- H2O2 induces nuclear transport of the receptor tyrosine kinase c-MET in breast cancer cells via a membrane-bound retrograde trafficking mechanism. Chen MK et al., 2019 May 24, J Biol ChemRead more
- NR5A1 prevents centriole splitting by inhibiting centrosomal DNA-PK activation and beta-catenin accumulation. Wang CY et al., 2014 Nov 25, Cell Commun SignalRead more
- Overexpression of TNKS1BP1 in lung cancers and its involvement in homologous recombination pathway of DNA double-strand breaks. Tan W et al., 2017 Feb, Cancer MedRead more