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ProductsBack/Ku80 antibody [N3C2], Internal
GTX109935 ICC/IF Image
GTX109935 ICC/IF Image
GTX109935 ICC/IF Image

Ku80 antibody [N3C2], Internal

Research Use Only
GTX109935
GeneTex
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Product group Antibodies
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More than 130 suppliers
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Overview

  • Supplier
    GeneTex
  • Product Name
    Ku80 antibody [N3C2], Internal
  • Delivery Days Customer
    9
  • Certification
    Research Use Only
  • Concentration
    0.41 mg/ml
  • Isotype
    IgG
  • Scientific Description
    The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq]
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352203

References

  • CSL controls telomere maintenance and genome stability in human dermal fibroblasts. Bottoni G et al., 2019 Aug 29, Nat Commun
    Read more
  • Effect of DNA damage response by quinazolinone analogue HMJ-38 on human umbilical vein endothelial cells: evidence for gammaH2A.X and DNA-PK-dependent pathway. Chiang JH et al., 2014 Jun, Hum Exp Toxicol
    Read more
  • H2O2 induces nuclear transport of the receptor tyrosine kinase c-MET in breast cancer cells via a membrane-bound retrograde trafficking mechanism. Chen MK et al., 2019 May 24, J Biol Chem
    Read more
  • Non-homologous end joining pathway is the major route of protection against 4beta-hydroxywithanolide E-induced DNA damage in MCF-7 cells. You BJ et al., 2014 Mar, Food Chem Toxicol
    Read more
  • Novel regulatory role for Kaposis sarcoma-associated herpesvirus-encoded vFLIP in chemosensitization to bleomycin. Masuda Y et al., 2011 Nov 18, Biochem Biophys Res Commun
    Read more
  • PHRF1 promotes genome integrity by modulating non-homologous end-joining. Chang CF et al., 2015 Apr 9, Cell Death Dis
    Read more
  • UVB Irradiation Induced Cell Damage and Early Onset of Junbb Expression in Zebrafish. Chen RY et al., 2020 Jun 25, Animals (Basel)
    Read more